Endocrine Abstracts

BACKGROUND: We have previously demonstrated that in weight losing gastrointestinal cancer patients appetite is poor despite low circulating leptin concentrations. One explanation for the apparent inability of these low circulating leptin concentrations to increase appetite might be a decrease in the leptin binding component resulting in high concentrations of 'free' biologically active leptin. The present study was designed to investigate this possibility, furthermore the effe...

Introduction: Bisphosphonate therapy (BPT) reduces osteoclast activity and may be associated with adynamic bone turnover. The extent of suppression of bone turnover and its determinants are unclear.Methods: Markers of bone metabolism were evaluated in 15 children (9M/6F) receiving cyclical BPT intravenously for osteoporosis. The median age at first biochemical assessment was 10.8 years (0.16, 16.3). Serum type I collagen cross-linked C-telopeptide (CTX),...